Apa Aja

In: Business and Management

Submitted By alif074
Words 1368
Pages 6
Warfarin
Stabilitas ¾ botol utuh harus disimpan pada suhu kamar dikendalikan dan dilindungi dari paparan sinar . Setelah dilarutkan, warfarin sodium secara fisik dan kimiawi stabil selama empat jam pada suhu kamar . Solusi dilarutkan tidak harus didinginkan . Jika salah satu partikel atau perubahan warna dicatat , obat harus dibuang . Solusi yang tidak terpakai juga harus dibuang . ( 1-10/06 )

Efek pH ¾ endapan A dapat membentuk dalam larutan karena pembentukan bentuk enol buruk larut warfarin pada nilai pH di bawah 8 . Pada pH 8 atau lebih tinggi , jelas stabil solusi hasil karena warfarin adalah dalam bentuk enolat larut . ( 964 )

Penyerapan ¾ Warfarin natrium ( Abbott ) 25 mg / L ditampilkan 11,7 % penyerapan ke plastik tes strip PVC dalam 24 jam . Kehadiran dextrose 5 % peningkatan tingkat penyerapan tersebut . ( 12 )

Warfarin natrium 22 mg / L dalam natrium klorida 0,9 % ( Travenol ) dalam kantong PVC dipamerkan sekitar 15% angka kerugian dalam satu minggu pada suhu kamar ( 15 sampai 20 ° C ) karena penyerapan . Namun, ketika larutan buffer dari pH awal dari 6,7-7,4 , tidak ada kerugian yang signifikan dari obat karena penyerapan diamati selama periode penelitian satu minggu . ( 536 )

Dalam studi lain, warfarin sodium 22 mg / L dalam natrium klorida 0,9 % tidak menunjukkan adanya kerugian akibat penyerapan selama infus simulasi tujuh jam melalui infus set ( Travenol ) yang terdiri dari selulosa propionat buret ruang dan 170 cm pipa PVC . ( 606 )

Obat itu juga diuji sebagai infus simulasi selama setidaknya satu jam dengan sistem pompa suntik . Sebuah jarum suntik kaca pada pompa suntik dilengkapi dengan 20 cm dari polietilen tabung atau 50 cm dari pipa Silastic . Tidak ada kehilangan obat karena penyerapan diamati dengan baik tabung . ( 606 )

Selain itu, alikuot 25 mL natrium warfarin 22 mg / L dalam natrium klorida 0,9 % yang disimpan dalam…...

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